Restylane/Perlane

Restylane® is a safe and natural cosmetic dermal filler that restores volume and fullness to the skin to correct facial wrinkles and folds, such as nasolabial folds.

Restylane® has a highly favorable safety profile. It is composed of non-animal stabilized hyaluronic acid. Hyaluronic acid is a substance found naturally in the human body. Restylane® is fully biocompatible. There is limited risk of animal-based disease transmission or development of allergic reactions to animal proteins. No allergy testing is required before use.

Restylane® maintains its shape using the body’s own moisture. The hyaluronic acid in Restylane is hydrophilic or “water loving.” As hyaluronic acid gradually degrades, each molecule binds to more water and over time, the same volume can be maintained with less hyaluronic acid. This ability of hyaluronic acid to bind to water is what helps provide long-lasting results.

Unlike rooster-derived hyaluronic acids and bovine collagen products, Restylane® is free from animal proteins. This limits any risk of animal-based disease transmissions or development of allergic reactions to animal proteins.

 

FAQ’S About Restylane:

What is Restylane®? 
A:
 Restylane® is a safe and natural cosmetic dermal filler that restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as nasolabial folds.

 

Q: What is Restylane® made of?
A: Restylane® is a cosmetic dermal filler composed of non-animal stabilized hyaluronic acid. Hyaluronic acid is a natural substance that already exists in the human body and is used to provide volume and fullness to the skin. The hyaluronic acid in Restylane® is a crystal-clear gel called NASHA™. NASHA is biodegradable and completely biocompatible with human hyaluronic acid.

Q: Is Restylane® an FDA approved product?
A: Restylane® is FDA approved to correct moderate to severe nasolabial folds. There are other areas in which Restylane® is injected to improve lines and wrinkles but these uses and areas are considered off-label at this time. The company, Medicis, which makes Restylane®, is currently awaiting more FDA approved indications.

Q: How do I choose between Restylane® vs JUVEDERM™?
A: This all depends on the person, location, personal preference, and provider’s experience with the product. Restylane® and JUVEDERM™ both contain hyaluronic acid and are used to soften lines and wrinkles and are used to restore volume. Even though, Restylane® and JUVEDERM™ have many similar properties, they are very different. I have some patients who love one or the other. Some say there is a better “look” to one product over the other which is something that person will know only after they have tried both.

Now, JUVEDERM™ is definitely smoother. Once JUVEDERM™ is injected into the skin, you don’t feel it. So for the lips and the nasolabial folds, these are great areas to do JUVEDERM™. If you are person who doesn’t want to “feel” the product, JUVEDERM™ probably will be the better choice.

Some patients like the feel of the product because they feel better knowing that they have the product and it is doing something in that desired area. For underneath the eyes, I prefer to use Restylane® because as the injector I feel I have more control of where the product goes. Also, I feel the granular consistency in Restylane® gives a better correction.

Longevity is also an issue. Restylane® around the nasolabial areas last 4-6 months. For JUVEDERM™, it could be the same or it can last longer. JUVEDERM™ uses hylacross technology which provides more cross linking between the different hylaronic acid molecules whereby it requires more time for the body to degrade it. Some of my patients feel it can last 9-12 months. This is certainly a determining factor for a lot of patients.

The JUVEDERM™ representatives say that injected JUVEDERM™ is less painful. I am not sure if I could say that yet.

Cost could be an issue. JUVEDERM™ is slightly more expensive. Restylane® does have a rewards program which gives cash back with every treatment and eventually a free syringe which is always nice. JUVEDERM™ does not have rewards program.

Another difference is that the JUVEDERM™ syringe has 0.2 cc less per syringe than Restylane®. Whether that makes a difference in correction requiring more syringes is still open for debate. This could theoretically require more syringes which will increase the total cost.

Q: What should patients do prior to treatment? 
A: Restylane® requires no pretesting, but you should take a few precautions before being treated. Avoid using aspirin, non-steroidal anti-inflammatory medication, St. John’s Wort, omega 3’s, or high doses of Vitamin E supplements prior to treatment, because these may increase bruising or bleeding at the injection site. Also, if you have previously suffered from facial cold sores, there is a risk that the needle punctures could contribute to another recurrence. You should notify your injector prior to having your injection so that you can get started on prophylactic antibiotics.

Q: Is Restylane® safe?
A: Yes. Restylane® has been used by dermatologists and plastic surgeons since 1996 worldwide. Restylane® has a highly favorable safety profile. It’s composed of non-animal stabilized hyaluronic acid, a substance found naturally in the human body. Restylane® is fully biocompatible. There is limited risk of animal-based disease transmission or development of allergic reactions to animal proteins. No allergy testing is required before use. The most commonly reported side effects are temporary injection-site redness, swelling, pain/tenderness, firmness, lumps/bumps, and bruising. These effects typically resolve in less than seven days.

Q: What are the Precautions of Restylane®?
• The safety of Restylane® for use during pregnancy, in breastfeeding females or in patients under 18 years has not been established.

• The safety of Restylane® in patients with increased susceptibility to keloid formation and hypertrophic scarring has not been studied. Restylane® should not be used in patients with known susceptibility to keloid formation or hypertrophic scarring.

• The patient should be informed that he or she should minimize exposure of the treated area to excessive sun and UV lamp exposure and extreme cold weather until any initial swelling and redness has resolved.

• If laser treatment, chemical peeling or any other procedure based on active dermal response is considered after treatment with Restylane® there is a possible risk of eliciting an inflammatory reaction at the implant site. This also applies if Restylane® is administered before the skin has healed completely after such a procedure.

Q: Can Restylane® be used anywhere on the face? 
A: Restylane® has been used in more than 3 million treatments in over 70 countries to correct a variety of wrinkles. It is currently FDA approved in the U.S. for the treatment of moderate to severe facial wrinkles and folds, such as nasolabial folds. Other popular areas such as underneath the eyes to improve hollowness under the eyes or in the cheeks for cheek enhancement or on the bridge of the nose to even the nose is considered off label.

Q: How long does Restylane® last?
A: Restylane® is proven to deliver long-lasting results. Studies have shown that Restylane® effects generally last for about six months or longer. The unique NASHA™ technology helps maintain the cosmetic effect until the injected material is nearly gone.

Q: How often should I have Restylane® treatments done?
A: Treatments are typically scheduled at 6 months to 12 months intervals depending on the treated area. Dr. Tang will discuss the appropriate follow-up treatments during your visit.

Q: Will I have any scars from the injections?
A: No.

Q: Will I be able to go back to work after the Restylane® injections?
A: Most of the time patients are able to go back to work the same day or the next day. All patients will have some redness and swelling immediately following the procedure which usually last 1-3 days. The redness and swelling are easily covered with makeup. Some patients will have some bruising which may last several days to 1 week. Some areas tend to bruise easier ie around the eyes. However, there is no absolute way of predicting who will bruise beforehand. There are several ways to help lessen bruising including icing, arnica, and avoiding medications such as Aspirin, anti-inflammatories, Vitamin E, and omega 3’s prior to the procedure. For more details, Dr. Tang will discuss all available methods to minimizing any potential bruising prior to the procedure.

Q: Do the injections hurt? 
A: Restylane® is injected directly into the skin in tiny amounts by an ultrafine needle, resulting in minimal discomfort. The procedure is simple and convenient, and the results are practically instantaneous. Some areas are more sensitive ie lips. To optimize your comfort during the short procedure, we anesthesize the area prior with a topical anesthetic and often will use dental blocks (similar to what dentists use). Medications prior to the treatment are not necessary.

Q: Can Restylane® be combined with lasers?
A: Yes. Restylane® can be combined with different types of lasers including laser resurfacing, IPL photofacials, and tightening lasers. Dr. Tang or his staff will discuss which types of treatments will provide the most optimal results.

Q: How much do Restylane® treatments cost? 
A: Restylane® is a customized procedure based on your specific needs, so the cost will vary from patient to patient. In general, the cost of Restylane® will depend on the number of syringes used. Dr. Tang or his staff will be able to give you an estimate prior to the procedure at no extra charge. In addition, Medicis, the makers of Restylane®, also provides a Rewards program that gives cash back and an eventual bonus syringe with each treatment.

Q: How is Restylane different from Botox®? 
A: Restylane® is a natural, cosmetic filler. In contrast, Botox® is a compound that blocks nerve transmission which relaxes the underlying muscles. They are used for different indications and because of this, they can be combined to enhance each other effects.

Q: What is the difference between Restylane® and Perlane®?
A: Restylane® and Perlane® are both composed of hyaluronic acid. Perlane® has larger gel particles and is intended to correct deeper lines and folds.

Q: Can you combine Restylane® and Perlane®?
A: It depends. For deeper lines and folds, the combination is an excellent way to correct the lines and folds with a smoother finish. For mild folds and lines, only Restylane® should be used.

Q: How is Restylane® different from bovine collagen? 
A: Bovine collagen is derived from animals (cow) and requires an allergy test. Restylane® can be administered without pretesting, so no waiting is required. With Restylane® there is limited risk of animal-based disease transmission or allergic reaction.

Lip Enhancement info video

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Restylane lip injection – Live Demo

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Perlane Live Patient Demo for Nasolabial Folds

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Research Articles

*The above pictures are actual patients but the individual results will vary and these results may not occur in all patients.

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